Microsphere technology extends the long-acting effect of ZILRETTA by localizing in the synovial tissue, which is a major source of OA knee pain and inflammation

ZILRETTA® (triamcinolone acetonide extended-release injectable suspension) is a novel formulation composed of triamcinolone acetonide (TA) embedded in a biodegradable PLGA matrix that extends residence time in the joint.1,2

ZILRETTA microsphere

Microspheres in the knee

  • After injection of ZILRETTA, microspheres localize on the synovium, away from the articular cartilage1,3
  • When in contact with synovial fluid, TA in the microsphere slowly dissolves1
  • After TA is released over time, microspheres degrade and are metabolized to CO2 and H2O1,2

Learn more about the microsphere technology of ZILRETTA

ZILRETTA is not interchangeable with other formulations of injectable triamcinolone acetonide.

PLGA=poly(lactic-co-glycolic acid).